5J8Z
Human carbonic anhydrase II in complex with ligand
Summary for 5J8Z
Entry DOI | 10.2210/pdb5j8z/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (6 entities in total) |
Functional Keywords | cytoplasm, lyase, 2-thio-6-oxo-1, 6-dihydropyrimidines, sulfonamides |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 30614.72 |
Authors | Alterio, V.,De Simone, G. (deposition date: 2016-04-08, release date: 2016-06-29, Last modification date: 2024-01-10) |
Primary citation | Vullo, D.,Supuran, C.T.,Scozzafava, A.,De Simone, G.,Monti, S.M.,Alterio, V.,Carta, F. Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors. Bioorg.Med.Chem., 24:3643-3648, 2016 Cited by PubMed: 27316543DOI: 10.1016/j.bmc.2016.06.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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