5J8X

CRYSTAL STRUCTURE OF E. COLI PBP5 WITH 2C

5J8X の概要

• エントリーDOI: 10.2210/pdb5j8x/pdb
• 分子名称: D-alanyl-D-alanine carboxypeptidase DacA, (4~{R})-4-[[4-(aminomethyl)phenyl]carbonylamino]-3,3-bis(oxidanyl)-2-oxa-3-boranuidabicyclo[4.4.0]deca-1(10),6,8-triene-10-carboxylic acid (3 entities in total)
• 機能のキーワード: antibiotic resistance, penicillin binding protein, boronic acid, hydrolase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42840.31

構造登録者

Brem, J.,Cain, R.,McDonough, M.A.,Clifton, I.J.,Fishwick, C.W.G.,Schofield, C.J. (登録日: 2016-04-08, 公開日: 2016-08-17, 最終更新日: 2024-01-10)

• 主引用文献: Brem, J.,Cain, R.,Cahill, S.,McDonough, M.A.,Clifton, I.J.,Jimenez-Castellanos, J.C.,Avison, M.B.,Spencer, J.,Fishwick, C.W.,Schofield, C.J.; Structural basis of metallo-beta-lactamase, serine-beta-lactamase and penicillin-binding protein inhibition by cyclic boronates.; Nat Commun, 7:12406-12406, 2016; PubMed: 27499424; DOI: 10.1038/ncomms12406

実験手法

X-RAY DIFFRACTION (2.53 Å)