5J8R

Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 12 - K61R mutant

Summary for 5J8R

Entry DOI	10.2210/pdb5j8r/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 12 (2 entities in total)
Functional Keywords	cancer, tyrosine phosphorylation, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q05209
Total number of polymer chains	4
Total formula weight	148185.00
Authors	Li, H.,Yang, F.,Xu, Y.F.,Wang, W.J.,Xiao, P.,Yu, X.,Sun, J.P. (deposition date: 2016-04-08, release date: 2016-04-27, Last modification date: 2023-11-08)
Primary citation	Li, H.,Yang, F.,Liu, C.,Xiao, P.,Xu, Y.F.,Liang, Z.L.,Liu, C.,Wang, H.M.,Wang, W.J.,Zheng, W.S.,Zhang, W.,Ma, X.Y.,He, D.F.,Song, X.Y.,Cui, F.A.,Xu, Z.G.,Yi, F.,Sun, J.P.,Yu, X. Crystal structure and substrate specificity of PTPN12. Cell Rep, 15:1-14, 2016 Cited by PubMed: 27134172 DOI: 10.1016/j.celrep.2016.04.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.043 Å)

Structure validation