5J7U

Faustovirus major capsid protein

5J7U の概要

• エントリーDOI: 10.2210/pdb5j7u/pdb
• 関連するPDBエントリー: 5J7O 5J7V
• EMDBエントリー: 8144 8145
• 分子名称: major capsid protein, unknown (3 entities in total)
• 機能のキーワード: virus, capsid, double jelly-roll, viral protein
• 由来する生物種: Faustovirus; 詳細
• タンパク質・核酸の鎖数: 24
• 化学式量合計: 883045.28

構造登録者

Klose, T.,Rossmann, M.G. (登録日: 2016-04-06, 公開日: 2016-05-18, 最終更新日: 2023-09-27)

主引用文献

Klose, T.,Reteno, D.G.,Benamar, S.,Hollerbach, A.,Colson, P.,La Scola, B.,Rossmann, M.G.
Structure of faustovirus, a large dsDNA virus.
Proc.Natl.Acad.Sci.USA, 113:6206-6211, 2016

PubMed Abstract: Many viruses protect their genome with a combination of a protein shell with or without a membrane layer. Here we describe the structure of faustovirus, the first DNA virus (to our knowledge) that has been found to use two protein shells to encapsidate and protect its genome. The crystal structure of the major capsid protein, in combination with cryo-electron microscopy structures of two different maturation stages of the virus, shows that the outer virus shell is composed of a double jelly-roll protein that can be found in many double-stranded DNA viruses. The structure of the repeating hexameric unit of the inner shell is different from all other known capsid proteins. In addition to the unique architecture, the region of the genome that encodes the major capsid protein stretches over 17,000 bp and contains a large number of introns and exons. This complexity might help the virus to rapidly adapt to new environments or hosts.

PubMed: 27185929
DOI: 10.1073/pnas.1523999113

実験手法

X-RAY DIFFRACTION (2.44 Å)