5J74

Fluorogen activating protein AM2.2 in complex with TO1-2p

Summary for 5J74

• Entry DOI: 10.2210/pdb5j74/pdb
• Related: 5J75
• Descriptor: scFv AM2.2, PHOSPHATE ION, 1-(17-amino-5,8-dioxo-12,15-dioxa-4,9-diazaheptadecan-1-yl)-4-{[3-(3-sulfopropyl)-1,3-benzothiazol-3-ium-2-yl]methyl}quinolin-1-ium, ... (4 entities in total)
• Functional Keywords: fluorogen activating protein drug discovery biosensor protein trafficking, protein binding, immune system
• Biological source: Homo sapiens
• Total number of polymer chains: 2
• Total formula weight: 56081.26

Authors

Stanfield, R.L.,Wilson, I.A.,Wu, Y. (deposition date: 2016-04-05, release date: 2016-05-25, Last modification date: 2023-09-27)

• Primary citation: Wu, Y.,Stauffer, S.R.,Stanfield, R.L.,Tapia, P.H.,Ursu, O.,Fisher, G.W.,Szent-Gyorgyi, C.,Evangelisti, A.,Waller, A.,Strouse, J.J.,Carter, M.B.,Bologa, C.,Gouveia, K.,Poslusney, M.,Waggoner, A.S.,Lindsley, C.W.,Jarvik, J.W.,Sklar, L.A.; Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen-Fluorogen Activating Protein Binding Pair.; J Biomol Screen, 21:74-87, 2016; PubMed: 26442911; DOI: 10.1177/1087057115609145

Experimental method

X-RAY DIFFRACTION (2.7 Å)