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5J64

Crystal Structure of Hsp90-alpha N-domain in complex with 5-(2,4-Dihydroxy-phenyl)-4-(2-fluoro-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

Summary for 5J64
Entry DOI10.2210/pdb5j64/pdb
DescriptorHeat shock protein HSP 90-alpha, 5-(2,4-dihydroxyphenyl)-4-(2-fluorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (3 entities in total)
Functional Keywordscomplex structure, chaperone
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : P07900
Total number of polymer chains1
Total formula weight25944.01
Authors
Amaral, M.,Matias, P. (deposition date: 2016-04-04, release date: 2017-12-06, Last modification date: 2024-01-10)
Primary citationAmaral, M.,Kokh, D.B.,Bomke, J.,Wegener, A.,Buchstaller, H.P.,Eggenweiler, H.M.,Matias, P.,Sirrenberg, C.,Wade, R.C.,Frech, M.
Protein conformational flexibility modulates kinetics and thermodynamics of drug binding.
Nat Commun, 8:2276-2276, 2017
Cited by
PubMed: 29273709
DOI: 10.1038/s41467-017-02258-w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.38 Å)
Structure validation

221051

数据于2024-06-12公开中

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