5J4K

Structure of humanised RadA-mutant humRadA22F in complex with 1-Indane-6-carboxylic acid

Summary for 5J4K

Entry DOI	10.2210/pdb5j4k/pdb
Descriptor	DNA repair and recombination protein RadA, SODIUM ION, CALCIUM ION, ... (6 entities in total)
Functional Keywords	dna repair, fragment based drug design, humanisation, hydrolase
Biological source	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Total number of polymer chains	1
Total formula weight	25739.23
Authors	Fischer, G.,Marsh, M.,Moschetti, T.,Sharpe, T.,Scott, D.,Morgan, M.,Ng, H.,Skidmore, J.,Venkitaraman, A.,Abell, C.,Blundell, T.L.,Hyvonen, M. (deposition date: 2016-04-01, release date: 2016-10-26, Last modification date: 2023-03-29)
Primary citation	Moschetti, T.,Sharpe, T.,Fischer, G.,Marsh, M.E.,Ng, H.K.,Morgan, M.,Scott, D.E.,Blundell, T.L.,R Venkitaraman, A.,Skidmore, J.,Abell, C.,Hyvonen, M. Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J.Mol.Biol., 428:4589-4607, 2016 Cited by PubMed: 27725183 DOI: 10.1016/j.jmb.2016.10.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.346 Å)

Structure validation