5J44

Crystal structure of the Secreted Extracellular protein A (SepA) from Shigella flexneri

Summary for 5J44

Entry DOI	10.2210/pdb5j44/pdb
Descriptor	Serine protease SepA autotransporter, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID (3 entities in total)
Functional Keywords	protease, beta-helix, secreted, hydrolase
Biological source	Shigella flexneri
Total number of polymer chains	2
Total formula weight	219039.02
Authors	Birtley, J.R.,Stern, L.J.,McCormick, B.,Maldonado-Contreras, A. (deposition date: 2016-03-31, release date: 2017-04-12, Last modification date: 2023-09-27)
Primary citation	Maldonado-Contreras, A.,Birtley, J.R.,Boll, E.,Zhao, Y.,Mumy, K.L.,Toscano, J.,Ayehunie, S.,Reinecker, H.C.,Stern, L.J.,McCormick, B.A. Shigella depends on SepA to destabilize the intestinal epithelial integrity via cofilin activation. Gut Microbes, 8:544-560, 2017 Cited by PubMed: 28598765 DOI: 10.1080/19490976.2017.1339006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.912 Å)

Structure validation