5J41

Glutathione S-transferase bound with hydrolyzed Piperlongumine

5J41 の概要

• エントリーDOI: 10.2210/pdb5j41/pdb
• 分子名称: Glutathione S-transferase P, 3-(3,4,5-trimethoxyphenyl)propanoic acid, GLUTATHIONE, ... (5 entities in total)
• 機能のキーワード: gstp1, piperlongumine, glutathione, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : P09211
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47978.76

構造登録者

Harshbarger, W.,Gondi, S.,Ficarro, S.,Hunter, J.,Udayakumar, D.,Gurbani, D.,Marto, J.,Westover, K. (登録日: 2016-03-31, 公開日: 2016-11-30, 最終更新日: 2023-09-27)

• 主引用文献: Harshbarger, W.,Gondi, S.,Ficarro, S.B.,Hunter, J.,Udayakumar, D.,Gurbani, D.,Singer, W.D.,Liu, Y.,Li, L.,Marto, J.A.,Westover, K.D.; Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine.; J. Biol. Chem., 292:112-120, 2017; PubMed: 27872191; DOI: 10.1074/jbc.M116.750299

実験手法

X-RAY DIFFRACTION (1.19035345576 Å)