5J3L

Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-((2-cyclopentylethyl)sulfonyl)pyrrolidine at 1.66A resolution

5J3L の概要

• エントリーDOI: 10.2210/pdb5j3l/pdb
• 分子名称: HTH-type transcriptional regulator EthR, 1-[(2-cyclopentylethyl)sulfonyl]pyrrolidine (3 entities in total)
• 機能のキーワード: ethr, transcription, represor, boosting effect
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24013.06

構造登録者

Blaszczyk, M.,Surade, S.,Nikiforov, P.O.,Abell, C.,Blundell, T.L. (登録日: 2016-03-31, 公開日: 2017-03-29, 最終更新日: 2024-01-10)

• 主引用文献: Nikiforov, P.O.,Blaszczyk, M.,Surade, S.,Boshoff, H.I.,Sajid, A.,Delorme, V.,Deboosere, N.,Brodin, P.,Baulard, A.R.,Barry, C.E.,Blundell, T.L.,Abell, C.; Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.; ACS Chem. Biol., 12:1390-1396, 2017; PubMed: 28314097; DOI: 10.1021/acschembio.7b00091

実験手法

X-RAY DIFFRACTION (1.66 Å)