5J1V
Crystal structure of human CLK1 in complex with pyrido[3,4-g]quinazoline derivative ZW29 (compound 13)
5J1V の概要
エントリーDOI | 10.2210/pdb5j1v/pdb |
分子名称 | Dual specificity protein kinase CLK1, pyrido[3,4-g]quinazoline-2,10-diamine, GLYCEROL, ... (4 entities in total) |
機能のキーワード | transferase, serine/threonine-protein kinase, tyrosine-protein kinase, nucleus, inhibitor, structural genomics consortium, sgc |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Nucleus: P49759 |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 119562.39 |
構造登録者 | Chaikuad, A.,Esvan, Y.J.,Zeinyeh, W.,Boibessot, T.,Nauton, L.,Thery, V.,Loaec, N.,Meijer, L.,Giraud, F.,Moreau, P.,Anizon, F.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2016-03-29, 公開日: 2016-05-04, 最終更新日: 2024-01-10) |
主引用文献 | Esvan, Y.J.,Zeinyeh, W.,Boibessot, T.,Nauton, L.,Thery, V.,Knapp, S.,Chaikuad, A.,Loaec, N.,Meijer, L.,Anizon, F.,Giraud, F.,Moreau, P. Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure. Eur.J.Med.Chem., 118:170-177, 2016 Cited by PubMed: 27128181DOI: 10.1016/j.ejmech.2016.04.004 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.52 Å) |
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