5J1R
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 3-(furan-3-yl)-1-(pyrrolidin-1-yl)propan-1-one at 1.92A resolution
Summary for 5J1R
Entry DOI | 10.2210/pdb5j1r/pdb |
Descriptor | EthR, 3-(furan-3-yl)-1-(pyrrolidin-1-yl)propan-1-one (3 entities in total) |
Functional Keywords | ethr, transcription, represor, boosting effect |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 1 |
Total formula weight | 23974.95 |
Authors | Blaszczyk, M.,Surade, S.,Nikiforov, P.O.,Abell, C.,Blundell, T.L. (deposition date: 2016-03-29, release date: 2017-03-29, Last modification date: 2024-01-10) |
Primary citation | Nikiforov, P.O.,Blaszczyk, M.,Surade, S.,Boshoff, H.I.,Sajid, A.,Delorme, V.,Deboosere, N.,Brodin, P.,Baulard, A.R.,Barry, C.E.,Blundell, T.L.,Abell, C. Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. ACS Chem. Biol., 12:1390-1396, 2017 Cited by PubMed: 28314097DOI: 10.1021/acschembio.7b00091 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
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