5J1A

Antigen presenting molecule

5J1A の概要

• エントリーDOI: 10.2210/pdb5j1a/pdb
• 分子名称: T-cell surface glycoprotein CD1a, Beta-2-microglobulin, 3-[(8Z,11Z)-pentadeca-8,11-dien-1-yl]benzene-1,2-diol, ... (4 entities in total)
• 機能のキーワード: cd1 molecules immunity, immune system-inhibitor complex, immune system/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane ; Single- pass type I membrane protein : P06126; Secreted . Note=(Microbial infection) In the presence of M: P61769
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48248.61

構造登録者

Yongqing, T.,Rossjohn, J.,Le Nours, J.,Marquez, E.,Winau, F. (登録日: 2016-03-29, 公開日: 2016-08-03, 最終更新日: 2024-11-06)

主引用文献

Kim, J.H.,Hu, Y.,Yongqing, T.,Kim, J.,Hughes, V.A.,Le Nours, J.,Marquez, E.A.,Purcell, A.W.,Wan, Q.,Sugita, M.,Rossjohn, J.,Winau, F.
CD1a on Langerhans cells controls inflammatory skin disease.
Nat. Immunol., 17:1159-1166, 2016

PubMed Abstract: CD1a is a lipid-presenting molecule that is abundantly expressed on Langerhans cells. However, the in vivo role of CD1a has remained unclear, principally because CD1a is lacking in mice. Through the use of mice with transgenic expression of CD1a, we found that the plant-derived lipid urushiol triggered CD1a-dependent skin inflammation driven by CD4(+) helper T cells that produced the cytokines IL-17 and IL-22 (TH17 cells). Human subjects with poison-ivy dermatitis had a similar cytokine signature following CD1a-mediated recognition of urushiol. Among various urushiol congeners, we identified diunsaturated pentadecylcatechol (C15:2) as the dominant antigen for CD1a-restricted T cells. We determined the crystal structure of the CD1a-urushiol (C15:2) complex, demonstrating the molecular basis of urushiol interaction with the antigen-binding cleft of CD1a. In a mouse model and in patients with psoriasis, CD1a amplified inflammatory responses that were mediated by TH17 cells that reacted to self lipid antigens. Treatment with blocking antibodies to CD1a alleviated skin inflammation. Thus, we propose CD1a as a potential therapeutic target in inflammatory skin diseases.

PubMed: 27548435
DOI: 10.1038/ni.3523

実験手法

X-RAY DIFFRACTION (1.86 Å)