Protein-protein interaction

Summary for 5IZA

Related5IZ6 5IZ8 5IZ9
DescriptorAdenomatous polyposis coli protein, ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2 (3 entities in total)
Functional Keywordsapc, asef, colon cancer, drug discovery, protein binding-inhibitor complex, protein binding/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight39995.05
Zhao, Y.,Jiang, H.,Yang, X.,Jiang, F.,Song, K.,Zhang, J. (deposition date: 2016-03-25, release date: 2017-07-05, Last modification date: 2019-01-23)
Primary citation
Jiang, H.,Deng, R.,Yang, X.,Shang, J.,Lu, S.,Zhao, Y.,Song, K.,Liu, X.,Zhang, Q.,Chen, Y.,Chinn, Y.E.,Wu, G.,Li, J.,Chen, G.,Yu, J.,Zhang, J.
Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13:994-1001, 2017
PubMed: 28759015 (PDB entries with the same primary citation)
DOI: 10.1038/nchembio.2442
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.16040 1.4% 3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5iza
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Molmil generated image of 5iza
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Molmil generated image of 5iza
rotated about y axis by 90°