5IZA

Protein-protein interaction

Summary for 5IZA

• Entry DOI: 10.2210/pdb5iza/pdb
• Related: 5IZ6 5IZ8 5IZ9
• Descriptor: Adenomatous polyposis coli protein, ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2 (3 entities in total)
• Functional Keywords: apc, asef, colon cancer, drug discovery, protein binding-inhibitor complex, protein binding/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 39995.05

Authors

Zhao, Y.,Jiang, H.,Yang, X.,Jiang, F.,Song, K.,Zhang, J. (deposition date: 2016-03-25, release date: 2017-07-05, Last modification date: 2023-11-08)

• Primary citation: Jiang, H.,Deng, R.,Yang, X.,Shang, J.,Lu, S.,Zhao, Y.,Song, K.,Liu, X.,Zhang, Q.,Chen, Y.,Chinn, Y.E.,Wu, G.,Li, J.,Chen, G.,Yu, J.,Zhang, J.; Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.; Nat. Chem. Biol., 13:994-1001, 2017; PubMed: 28759015; DOI: 10.1038/nchembio.2442

Experimental method

X-RAY DIFFRACTION (1.5 Å)