5IY0

PfMCM N-terminal domain double hexamer

5IY0 の概要

• エントリーDOI: 10.2210/pdb5iy0/pdb
• 分子名称: Cell division control protein 21, ZINC ION (2 entities in total)
• 機能のキーワード: replication, dna binding protein, replication dna binding protein
• 由来する生物種: Pyrococcus furiosus
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 176796.72

構造登録者

Meagher, M.,Enemark, E.J. (登録日: 2016-03-23, 公開日: 2016-07-13, 最終更新日: 2023-09-27)

主引用文献

Meagher, M.,Enemark, E.J.
Structure of a double hexamer of the Pyrococcus furiosus minichromosome maintenance protein N-terminal domain.
Acta Crystallogr.,Sect.F, 72:545-551, 2016

PubMed Abstract: The crystal structure of the N-terminal domain of the Pyrococcus furiosus minichromosome maintenance (MCM) protein as a double hexamer is described. The MCM complex is a ring-shaped helicase that unwinds DNA at the replication fork of eukaryotes and archaea. Prior to replication initiation, the MCM complex assembles as an inactive double hexamer at specific sites of DNA. The presented structure is highly consistent with previous MCM double-hexamer structures and shows two MCM hexamers with a head-to-head interaction mediated by the N-terminal domain. Minor differences include a diminished head-to-head interaction and a slightly reduced inter-hexamer rotation.

PubMed: 27380371
DOI: 10.1107/S2053230X1600858X

実験手法

X-RAY DIFFRACTION (3 Å)