5IWC

Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 3 [4-(3-([1,1'-Biphenyl]-3-yl)ureido)-2-hydroxybenzoic acid]

5IWC の概要

• エントリーDOI: 10.2210/pdb5iwc/pdb
• 関連するPDBエントリー: 3DKI 3FGP
• 分子名称: O-phosphoserine sulfhydrylase, PYRIDOXAL-5'-PHOSPHATE, 4-{[([1,1'-biphenyl]-3-yl)carbamoyl]amino}-2-hydroxybenzoic acid, ... (4 entities in total)
• 機能のキーワード: mycobacterium tuberculosis, cysteine biosynthesis, sulphur metabolism, inhibitor, lyase, transferase
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70639.22

構造登録者

Schnell, R.,Maric, S.,Lindqvist, Y.,Schneider, G. (登録日: 2016-03-22, 公開日: 2016-08-17, 最終更新日: 2024-01-10)

• 主引用文献: Brunner, K.,Maric, S.,Reshma, R.S.,Almqvist, H.,Seashore-Ludlow, B.,Gustavsson, A.L.,Poyraz, O.,Yogeeswari, P.,Lundback, T.,Vallin, M.,Sriram, D.,Schnell, R.,Schneider, G.; Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.; J.Med.Chem., 59:6848-6859, 2016; PubMed: 27379713; DOI: 10.1021/acs.jmedchem.6b00674

実験手法

X-RAY DIFFRACTION (2.7 Å)