5IRE

The cryo-EM structure of Zika Virus

5IRE の概要

• エントリーDOI: 10.2210/pdb5ire/pdb
• EMDBエントリー: 8116
• 分子名称: E protein, M protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: zika virus, virus
• 由来する生物種: Zika virus; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 190096.01

構造登録者

Sirohi, D.,Chen, Z.,Sun, L.,Klose, T.,Pierson, T.,Rossmann, M.,Kuhn, R. (登録日: 2016-03-13, 公開日: 2016-03-30, 最終更新日: 2024-11-13)

主引用文献

Sirohi, D.,Chen, Z.,Sun, L.,Klose, T.,Pierson, T.C.,Rossmann, M.G.,Kuhn, R.J.
The 3.8 angstrom resolution cryo-EM structure of Zika virus.
Science, 352:467-470, 2016

PubMed Abstract: The recent rapid spread of Zika virus and its unexpected linkage to birth defects and an autoimmune neurological syndrome have generated worldwide concern. Zika virus is a flavivirus like the dengue, yellow fever, and West Nile viruses. We present the 3.8 angstrom resolution structure of mature Zika virus, determined by cryo-electron microscopy (cryo-EM). The structure of Zika virus is similar to other known flavivirus structures, except for the ~10 amino acids that surround the Asn(154) glycosylation site in each of the 180 envelope glycoproteins that make up the icosahedral shell. The carbohydrate moiety associated with this residue, which is recognizable in the cryo-EM electron density, may function as an attachment site of the virus to host cells. This region varies not only among Zika virus strains but also in other flaviviruses, which suggests that differences in this region may influence virus transmission and disease.

PubMed: 27033547
DOI: 10.1126/science.aaf5316

実験手法

ELECTRON MICROSCOPY (3.8 Å)