5IRA

Expanding Nature's Catalytic Repertoire -Directed Evolution of an Artificial Metalloenzyme for In Vivo Metathesis

5IRA の概要

• エントリーDOI: 10.2210/pdb5ira/pdb
• 分子名称: Artificial Metathesase, [1-[4-[[5-[(3~{a}~{S},4~{S},6~{a}~{R})-2-oxidanylidene-1,3,3~{a},4,6,6~{a}-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]methyl]-2,6-dimethyl-phenyl]-3-(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-1-ium-2-yl]-bis(chloranyl)ruthenium (3 entities in total)
• 機能のキーワード: biotin-binding protein, beta barrel, metathesis, organometallic complex
• 由来する生物種: Streptomyces avidinii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17289.75

構造登録者

Heinisch, T.,Jeschek, M.,Reuter, R.,Trindler, C.,Panke, S.,Ward, T.R. (登録日: 2016-03-12, 公開日: 2016-08-31, 最終更新日: 2024-01-10)

• 主引用文献: Jeschek, M.,Reuter, R.,Heinisch, T.,Trindler, C.,Klehr, J.,Panke, S.,Ward, T.R.; Directed evolution of artificial metalloenzymes for in vivo metathesis.; Nature, 537:661-665, 2016; PubMed: 27571282; DOI: 10.1038/nature19114

実験手法

X-RAY DIFFRACTION (1.5 Å)