5IP6

Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with N-((tetrahydrofuran-3-yl)methyl)pyrrolidine-1-carboxamide at 1.93A resolution

5IP6 の概要

• エントリーDOI: 10.2210/pdb5ip6/pdb
• 分子名称: TetR-family transcriptional regulatory repressor protein, N-{[(3S)-oxolan-3-yl]methyl}pyrrolidine-1-carboxamide (3 entities in total)
• 機能のキーワード: ethr, transcription, represor, boosting effect
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23979.97

構造登録者

Blaszczyk, M.,Surade, S.,Nikiforov, P.O.,Abell, C.,Blundell, T.L. (登録日: 2016-03-09, 公開日: 2017-03-29, 最終更新日: 2024-01-10)

• 主引用文献: Nikiforov, P.O.,Blaszczyk, M.,Surade, S.,Boshoff, H.I.,Sajid, A.,Delorme, V.,Deboosere, N.,Brodin, P.,Baulard, A.R.,Barry, C.E.,Blundell, T.L.,Abell, C.; Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.; ACS Chem. Biol., 12:1390-1396, 2017; PubMed: 28314097; DOI: 10.1021/acschembio.7b00091

実験手法

X-RAY DIFFRACTION (1.93 Å)