5INH

Crystal structure of Autotaxin/ENPP2 with a covalent fragment

5INH の概要

• エントリーDOI: 10.2210/pdb5inh/pdb
• 分子名称: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 102907.16

構造登録者

Klein, M.G.,Tjhen, R. (登録日: 2016-03-07, 公開日: 2017-03-15, 最終更新日: 2020-07-29)

• 主引用文献: Lanier, M.,Cole, D.C.,Istratiy, Y.,Klein, M.G.,Schwartz, P.A.,Tjhen, R.,Jennings, A.,Hixon, M.S.; Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes.; J. Med. Chem., 60:5209-5215, 2017; PubMed: 28564542; DOI: 10.1021/acs.jmedchem.6b01224

実験手法

X-RAY DIFFRACTION (1.84 Å)