5IMU

A fragment of conserved hypothetical protein Rv3899c (residues 184-410) from Mycobacterium tuberculosis

5IMU の概要

• エントリーDOI: 10.2210/pdb5imu/pdb
• 分子名称: Tat (Twin-arginine translocation) pathway signal sequence containing protein, POTASSIUM ION (3 entities in total)
• 機能のキーワード: alpha/beta/alpha sandwich, alpha helix bundule, signaling protein
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24290.55

構造登録者

Li, D.F.,Gao, Y.R.,Liu, Y.Y.,Bi, L.J. (登録日: 2016-03-07, 公開日: 2017-03-08, 最終更新日: 2024-03-20)

主引用文献

Liu, Y.Y.,Gao, Y.R.,Li, D.F.,Fleming, J.,Li, H.L.,Bi, L.J.
Crystal structure of Rv3899c(184-410), a hypothetical protein from Mycobacterium tuberculosis
Acta Crystallogr F Struct Biol Commun, 72:642-645, 2016

PubMed Abstract: Rv3899c is a hypothetical protein from Mycobacterium tuberculosis which is conserved across mycobacteria. It is predicted to be secreted and has been found in culture filtrates. It has been proposed as a potential vaccine candidate; however, its biological function is unknown. Here, the global structure of Rv3899c(184-410), a fragment of Rv3899c, is reported. The structure resembles the shell of a sea snail, and its N- and C-termini form two relatively independent compact domains: an α/β/α sandwich folding domain and an α-helix bundle domain. There are no reported protein structures for any Rv3899c homologues; this structure provides the first structural glimpse of a new protein family consisting of Rv3899c and its homologues.

PubMed: 27487929
DOI: 10.1107/S2053230X16010943

実験手法

X-RAY DIFFRACTION (1.9 Å)