5IJS

Crystal structure of autotaxin with orthovanadate bound as a trigonal bipyramidal intermediate analog

Summary for 5IJS

Entry DOI	10.2210/pdb5ijs/pdb
Related	5dlt 5ijq
Descriptor	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, ... (8 entities in total)
Functional Keywords	hydrolase, lysophosphatidylcholine, somatomedin, inflammation, metastasis, neuropathic pain, vascular development, neural development
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	1
Total formula weight	96956.95
Authors	Hausmann, J.,Joosten, R.P.,Perrakis, A. (deposition date: 2016-03-02, release date: 2016-06-15, Last modification date: 2024-01-10)
Primary citation	Hausmann, J.,Keune, W.J.,Hipgrave Ederveen, A.L.,van Zeijl, L.,Joosten, R.P.,Perrakis, A. Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin. J.Struct.Biol., 195:199-206, 2016 Cited by PubMed: 27268273 DOI: 10.1016/j.jsb.2016.06.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation