5IGK
Crystal structure of the first bromodomain of human BRD4 in complex with bromosporine (BSP)
Summary for 5IGK
Entry DOI | 10.2210/pdb5igk/pdb |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, Bromosporine, ... (4 entities in total) |
Functional Keywords | transcription, post translational modifications, bet family, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15565.89 |
Authors | Filippakopoulos, P.,Picaud, S.,Felletar, I.,von Delft, F.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2016-02-28, release date: 2016-10-19, Last modification date: 2024-01-10) |
Primary citation | Picaud, S.,Leonards, K.,Lambert, J.P.,Dovey, O.,Wells, C.,Fedorov, O.,Monteiro, O.,Fujisawa, T.,Wang, C.Y.,Lingard, H.,Tallant, C.,Nikbin, N.,Guetzoyan, L.,Ingham, R.,Ley, S.V.,Brennan, P.,Muller, S.,Samsonova, A.,Gingras, A.C.,Schwaller, J.,Vassiliou, G.,Knapp, S.,Filippakopoulos, P. Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia. Sci Adv, 2:e1600760-e1600760, 2016 Cited by PubMed: 27757418DOI: 10.1126/sciadv.1600760 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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