5IGK

Crystal structure of the first bromodomain of human BRD4 in complex with bromosporine (BSP)

5IGK の概要

• エントリーDOI: 10.2210/pdb5igk/pdb
• 分子名称: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, Bromosporine, ... (4 entities in total)
• 機能のキーワード: transcription, post translational modifications, bet family, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15565.89

構造登録者

Filippakopoulos, P.,Picaud, S.,Felletar, I.,von Delft, F.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2016-02-28, 公開日: 2016-10-19, 最終更新日: 2024-01-10)

• 主引用文献: Picaud, S.,Leonards, K.,Lambert, J.P.,Dovey, O.,Wells, C.,Fedorov, O.,Monteiro, O.,Fujisawa, T.,Wang, C.Y.,Lingard, H.,Tallant, C.,Nikbin, N.,Guetzoyan, L.,Ingham, R.,Ley, S.V.,Brennan, P.,Muller, S.,Samsonova, A.,Gingras, A.C.,Schwaller, J.,Vassiliou, G.,Knapp, S.,Filippakopoulos, P.; Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.; Sci Adv, 2:e1600760-e1600760, 2016; PubMed: 27757418; DOI: 10.1126/sciadv.1600760

実験手法

X-RAY DIFFRACTION (1.7 Å)