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5IF1

Crystal structure apo CDK2/cyclin A

5IF1 の概要
エントリーDOI10.2210/pdb5if1/pdb
分子名称Cyclin-dependent kinase 2, Cyclin-A2 (3 entities in total)
機能のキーワードantineoplastic agents, cyclin-dependent kinases, dose-response relationship, drug, drug discovery, hela cells, molecular structure, neoplasms, protein kinase inhibitors, pyrimidines, structure-activity relationship, structure-kinetics relationship, sulfoxides, biophysical assays, tumor, humans, transferase
由来する生物種Homo sapiens (Human)
詳細
タンパク質・核酸の鎖数4
化学式量合計129117.55
構造登録者
Ayaz, P.,Andres, D.,Kwiatkowski, D.A.,Kolbe, C.,Lienau, P.,Siemeister, G.,Luecking, U.,Stegmann, C.M. (登録日: 2016-02-25, 公開日: 2016-04-27, 最終更新日: 2019-10-16)
主引用文献Ayaz, P.,Andres, D.,Kwiatkowski, D.A.,Kolbe, C.C.,Lienau, P.,Siemeister, G.,Lucking, U.,Stegmann, C.M.
Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9.
Acs Chem.Biol., 11:1710-1719, 2016
Cited by
PubMed: 27090615
DOI: 10.1021/acschembio.6b00074
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.61 Å)
構造検証レポート
Validation report summary of 5if1
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-04-24に公開中

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