5IEZ
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) inhibitors using Structure-Based Design
Summary for 5IEZ
Entry DOI | 10.2210/pdb5iez/pdb |
Related | 5IF4 |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, 3-({6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-indole-2-carbonyl}amino)benzoic acid (3 entities in total) |
Functional Keywords | myeloid cell leukemia-1, bcl-2, apoptosis, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 74623.93 |
Authors | Zhao, B. (deposition date: 2016-02-25, release date: 2017-01-18, Last modification date: 2024-03-06) |
Primary citation | Lee, T.,Bian, Z.,Zhao, B.,Hogdal, L.J.,Sensintaffar, J.L.,Goodwin, C.M.,Belmar, J.,Shaw, S.,Tarr, J.C.,Veerasamy, N.,Matulis, S.M.,Koss, B.,Fischer, M.A.,Arnold, A.L.,Camper, D.V.,Browning, C.F.,Rossanese, O.W.,Budhraja, A.,Opferman, J.,Boise, L.H.,Savona, M.R.,Letai, A.,Olejniczak, E.T.,Fesik, S.W. Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors. FEBS Lett., 591:240-251, 2017 Cited by PubMed: 27878989DOI: 10.1002/1873-3468.12497 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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