5IDK

Crystal structure of West Nile Virus NS2B-NS3 protease in complex with a capped dipeptide boronate inhibitor

5IDK の概要

• エントリーDOI: 10.2210/pdb5idk/pdb
• 分子名称: Genome polyprotein,SERINE PROTEASE SUBUNIT NS2B, SERINE PROTEASE NS3, ((R)-1-((S)-3-(4-(aminomethyl)phenyl)-2-benzamidopropaneamido)-4-guanidinobutyl)boronic acid, cyclic double ester with glycerol, DIMETHYL SULFOXIDE, ... (5 entities in total)
• 機能のキーワード: antivirus agents, peptides, west nile virus, boronic acid, viral protein
• 由来する生物種: West Nile virus (WNV); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 75508.54

構造登録者

Hilgenfeld, R.,Zhang, L. (登録日: 2016-02-24, 公開日: 2016-12-14, 最終更新日: 2024-01-10)

• 主引用文献: Nitsche, C.,Zhang, L.,Weigel, L.F.,Schilz, J.,Graf, D.,Bartenschlager, R.,Hilgenfeld, R.,Klein, C.D.; Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology.; J. Med. Chem., 60:511-516, 2017; PubMed: 27966962; DOI: 10.1021/acs.jmedchem.6b01021

実験手法

X-RAY DIFFRACTION (1.5 Å)