5IBD

Crystal structure Mycobacterium tuberculosis CYP121 in complex with inhibitor fragment 24a

Summary for 5IBD

Entry DOI	10.2210/pdb5ibd/pdb
Descriptor	Mycocyclosin synthase, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
Functional Keywords	mycobacterium tuberculosis cyp121, fragment based inhibitor screening, oxidoreductase
Biological source	Mycobacterium tuberculosis
Cellular location	Cytoplasm : P9WPP6
Total number of polymer chains	1
Total formula weight	44759.08
Authors	Levy, C. (deposition date: 2016-02-22, release date: 2016-04-06, Last modification date: 2024-05-01)
Primary citation	Kavanagh, M.E.,Coyne, A.G.,McLean, K.J.,James, G.G.,Levy, C.W.,Marino, L.B.,de Carvalho, L.P.,Chan, D.S.,Hudson, S.A.,Surade, S.,Leys, D.,Munro, A.W.,Abell, C. Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59:3272-3302, 2016 Cited by PubMed: 27002486 DOI: 10.1021/acs.jmedchem.6b00007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation