5IA3

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with PD173955

Summary for 5IA3

• Entry DOI: 10.2210/pdb5ia3/pdb
• Descriptor: Ephrin type-A receptor 2, 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE (3 entities in total)
• Functional Keywords: transferase, tyrosine-protein kinase, receptor, atp-binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 34906.19

Authors

Kudlinzki, D.,Linhard, V.L.,Gande, S.L.,Sreeramulu, S.,Saxena, K.,Heinzlmeir, S.,Medard, G.,Kuester, B.,Schwalbe, H. (deposition date: 2016-02-21, release date: 2016-11-09, Last modification date: 2024-01-10)

• Primary citation: Heinzlmeir, S.,Kudlinzki, D.,Sreeramulu, S.,Klaeger, S.,Gande, S.L.,Linhard, V.,Wilhelm, M.,Qiao, H.,Helm, D.,Ruprecht, B.,Saxena, K.,Medard, G.,Schwalbe, H.,Kuster, B.; Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.; ACS Chem. Biol., 11:3400-3411, 2016; PubMed: 27768280; DOI: 10.1021/acschembio.6b00709

Experimental method

X-RAY DIFFRACTION (1.788 Å)