5I9Z

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with danusertib (PHA739358)

5I9Z の概要

• エントリーDOI: 10.2210/pdb5i9z/pdb
• 分子名称: Ephrin type-A receptor 2, N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: transferase, tyrosine-protein kinase, receptor, atp-binding
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34999.46

構造登録者

Kudlinzki, D.,Linhard, V.L.,Gande, S.L.,Sreeramulu, S.,Saxena, K.,Heinzlmeir, S.,Medard, G.,Kuester, B.,Schwalbe, H. (登録日: 2016-02-21, 公開日: 2016-11-09, 最終更新日: 2024-01-10)

• 主引用文献: Heinzlmeir, S.,Kudlinzki, D.,Sreeramulu, S.,Klaeger, S.,Gande, S.L.,Linhard, V.,Wilhelm, M.,Qiao, H.,Helm, D.,Ruprecht, B.,Saxena, K.,Medard, G.,Schwalbe, H.,Kuster, B.; Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.; ACS Chem. Biol., 11:3400-3411, 2016; PubMed: 27768280; DOI: 10.1021/acschembio.6b00709

実験手法

X-RAY DIFFRACTION (1.698 Å)