5I9Y

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with dasatinib

Summary for 5I9Y

• Entry DOI: 10.2210/pdb5i9y/pdb
• Descriptor: Ephrin type-A receptor 2, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: transferase, tyrosine-protein kinase, receptor, atp-binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 35137.05

Authors

Kudlinzki, D.,Linhard, V.L.,Gande, S.L.,Sreeramulu, S.,Saxena, K.,Heinzlmeir, S.,Medard, G.,Kuester, B.,Schwalbe, H. (deposition date: 2016-02-21, release date: 2016-11-09, Last modification date: 2024-01-10)

• Primary citation: Heinzlmeir, S.,Kudlinzki, D.,Sreeramulu, S.,Klaeger, S.,Gande, S.L.,Linhard, V.,Wilhelm, M.,Qiao, H.,Helm, D.,Ruprecht, B.,Saxena, K.,Medard, G.,Schwalbe, H.,Kuster, B.; Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.; ACS Chem. Biol., 11:3400-3411, 2016; PubMed: 27768280; DOI: 10.1021/acschembio.6b00709

Experimental method

X-RAY DIFFRACTION (1.228 Å)