5I8B

CBP in complex with Cpd23 ((R)-6-(3-(benzyloxy)phenyl)-4-methyl-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one)

5I8B の概要

• エントリーDOI: 10.2210/pdb5i8b/pdb
• 分子名称: CREB-binding protein, ZINC ION, (4R)-6-[3-(benzyloxy)phenyl]-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, ... (8 entities in total)
• 機能のキーワード: crebbp, bromodomain, epigenetics, structure-based drug design, transcription-protein binding complex, transcription/protein binding
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q92793
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32495.83

構造登録者

Murray, J.M. (登録日: 2016-02-18, 公開日: 2016-04-20, 最終更新日: 2024-03-06)

• 主引用文献: Taylor, A.M.,Cote, A.,Hewitt, M.C.,Pastor, R.,Leblanc, Y.,Nasveschuk, C.G.,Romero, F.A.,Crawford, T.D.,Cantone, N.,Jayaram, H.,Setser, J.,Murray, J.,Beresini, M.H.,de Leon Boenig, G.,Chen, Z.,Conery, A.R.,Cummings, R.T.,Dakin, L.A.,Flynn, E.M.,Huang, O.W.,Kaufman, S.,Keller, P.J.,Kiefer, J.R.,Lai, T.,Li, Y.,Liao, J.,Liu, W.,Lu, H.,Pardo, E.,Tsui, V.,Wang, J.,Wang, Y.,Xu, Z.,Yan, F.,Yu, D.,Zawadzke, L.,Zhu, X.,Zhu, X.,Sims, R.J.,Cochran, A.G.,Bellon, S.,Audia, J.E.,Magnuson, S.,Albrecht, B.K.; Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).; Acs Med.Chem.Lett., 7:531-536, 2016; PubMed: 27190605; DOI: 10.1021/acsmedchemlett.6b00075

実験手法

X-RAY DIFFRACTION (1.5218 Å)