5I6T

Crystal structure of color device state C

5I6T の概要

• エントリーDOI: 10.2210/pdb5i6t/pdb
• 関連するPDBエントリー: 5I36 5I6Q
• 分子名称: DNA (5'-D(*GP*TP*CP*CP*TP*AP*CP*CP*TP*GP*GP*CP*AP*GP*GP*AP*CP*GP*AP*CP*T)-3'), DNA (26-MER), DNA (5'-D(*TP*CP*TP*GP*AP*TP*GP*TP*GP*GP*TP*AP*GP*G)-3'), ... (8 entities in total)
• 機能のキーワード: tensegrity triangle, single strand extending, dna
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 41661.06

構造登録者

Hao, Y.,Birktoft, J.,Seeman, N.C. (登録日: 2016-02-16, 公開日: 2017-01-18, 最終更新日: 2023-09-27)

主引用文献

Hao, Y.,Kristiansen, M.,Sha, R.,Birktoft, J.J.,Hernandez, C.,Mao, C.,Seeman, N.C.
A device that operates within a self-assembled 3D DNA crystal.
Nat Chem, 9:824-827, 2017

PubMed Abstract: Structural DNA nanotechnology finds applications in numerous areas, but the construction of objects, 2D and 3D crystalline lattices and devices is prominent among them. Each of these components has been developed individually, and most of them have been combined in pairs. However, to date there are no reports of independent devices contained within 3D crystals. Here we report a three-state 3D device whereby we change the colour of the crystals by diffusing strands that contain dyes in or out of the crystals through the mother-liquor component of the system. Each colouring strand is designed to pair with an extended triangle strand by Watson-Crick base pairing. The arm that contains the dyes is quite flexible, but it is possible to establish the presence of the duplex proximal to the triangle by X-ray crystallography. We modelled the transition between the red and blue states through a simple kinetic model.

PubMed: 28754940
DOI: 10.1038/nchem.2745

実験手法

X-RAY DIFFRACTION (5.283 Å)