5I60
X-RAY CRYSTAL STRUCTURE AT 2.12A RESOLUTION OF HUMAN MITOCHONDRIAL BRANCHED CHAIN AMINOTRANSFERASE (BCATM) COMPLEXED WITH A BIARL AMIDE COMPOUND AND AN INTERNAL ALDIMINE LINKED PLP COFACTOR.
Summary for 5I60
Entry DOI | 10.2210/pdb5i60/pdb |
Related | 5I5S 5I5T 5I5U 5I5V 5I5W 5I5X 5I5Y |
Descriptor | Branched-chain-amino-acid aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE, (2-{[4-(1H-pyrazol-3-yl)phenyl]carbamoyl}phenyl)acetic acid, ... (6 entities in total) |
Functional Keywords | fold type iv, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform A: Mitochondrion. Isoform B: Cytoplasm: O15382 |
Total number of polymer chains | 2 |
Total formula weight | 85217.24 |
Authors | Somers, D.O. (deposition date: 2016-02-15, release date: 2016-03-23, Last modification date: 2024-05-01) |
Primary citation | Borthwick, J.A.,Ancellin, N.,Bertrand, S.M.,Bingham, R.P.,Carter, P.S.,Chung, C.W.,Churcher, I.,Dodic, N.,Fournier, C.,Francis, P.L.,Hobbs, A.,Jamieson, C.,Pickett, S.D.,Smith, S.E.,Somers, D.O.,Spitzfaden, C.,Suckling, C.J.,Young, R.J. Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening. J.Med.Chem., 59:2452-2467, 2016 Cited by PubMed: 26938474DOI: 10.1021/acs.jmedchem.5b01607 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.12 Å) |
Structure validation
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