5I5W

X-RAY CRYSTAL STRUCTURE AT 2.40A RESOLUTION OF HUMAN MITOCHONDRIAL BRANCHED CHAIN AMINOTRANSFERASE (BCATM) COMPLEXED WITH A BIARYL AMIDE COMPOUND AND AN INTERNAL ALDIMINE LINKED PLP COFACTOR.

Summary for 5I5W

Entry DOI	10.2210/pdb5i5w/pdb
Related	5I5S 5I5T 5I5U 5I5V 5I5X 5I5Y 5I6O
Descriptor	Branched-chain-amino-acid aminotransferase, mitochondrial, N-(pyrimidin-5-yl)benzamide, PYRIDOXAL-5'-PHOSPHATE, ... (7 entities in total)
Functional Keywords	fold type iv, transferase
Biological source	Homo sapiens (Human)
Cellular location	Isoform A: Mitochondrion. Isoform B: Cytoplasm: O15382
Total number of polymer chains	2
Total formula weight	85136.00
Authors	Somers, D.O. (deposition date: 2016-02-15, release date: 2016-03-23, Last modification date: 2024-05-01)
Primary citation	Borthwick, J.A.,Ancellin, N.,Bertrand, S.M.,Bingham, R.P.,Carter, P.S.,Chung, C.W.,Churcher, I.,Dodic, N.,Fournier, C.,Francis, P.L.,Hobbs, A.,Jamieson, C.,Pickett, S.D.,Smith, S.E.,Somers, D.O.,Spitzfaden, C.,Suckling, C.J.,Young, R.J. Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening. J.Med.Chem., 59:2452-2467, 2016 Cited by PubMed: 26938474 DOI: 10.1021/acs.jmedchem.5b01607 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation