5I5W

X-RAY CRYSTAL STRUCTURE AT 2.40A RESOLUTION OF HUMAN MITOCHONDRIAL BRANCHED CHAIN AMINOTRANSFERASE (BCATM) COMPLEXED WITH A BIARYL AMIDE COMPOUND AND AN INTERNAL ALDIMINE LINKED PLP COFACTOR.

5I5W の概要

• エントリーDOI: 10.2210/pdb5i5w/pdb
• 関連するPDBエントリー: 5I5S 5I5T 5I5U 5I5V 5I5X 5I5Y 5I6O
• 分子名称: Branched-chain-amino-acid aminotransferase, mitochondrial, N-(pyrimidin-5-yl)benzamide, PYRIDOXAL-5'-PHOSPHATE, ... (7 entities in total)
• 機能のキーワード: fold type iv, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform A: Mitochondrion. Isoform B: Cytoplasm: O15382
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 85136.00

構造登録者

Somers, D.O. (登録日: 2016-02-15, 公開日: 2016-03-23, 最終更新日: 2024-05-01)

• 主引用文献: Borthwick, J.A.,Ancellin, N.,Bertrand, S.M.,Bingham, R.P.,Carter, P.S.,Chung, C.W.,Churcher, I.,Dodic, N.,Fournier, C.,Francis, P.L.,Hobbs, A.,Jamieson, C.,Pickett, S.D.,Smith, S.E.,Somers, D.O.,Spitzfaden, C.,Suckling, C.J.,Young, R.J.; Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening.; J.Med.Chem., 59:2452-2467, 2016; PubMed: 26938474; DOI: 10.1021/acs.jmedchem.5b01607

実験手法

X-RAY DIFFRACTION (2.4 Å)