5I5N

Crystal Structure of N-terminal Domain of Matrix Protein of Thogoto Virus at Acidic pH.

5I5N の概要

• エントリーDOI: 10.2210/pdb5i5n/pdb
• 関連するPDBエントリー: 5I5O
• 分子名称: Matrix protein (2 entities in total)
• 機能のキーワード: viral protein
• 由来する生物種: Thogoto virus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34431.45

構造登録者

Liu, Y.,Liang, H.,Yang, M. (登録日: 2016-02-15, 公開日: 2016-08-17, 最終更新日: 2024-03-20)

主引用文献

Yang, M.,Feng, F.,Liu, Y.,Wang, H.,Yang, Z.,Hou, W.,Liang, H.
pH-dependent conformational changes of a Thogoto virus matrix protein reveal mechanisms of viral assembly and uncoating
J.Gen.Virol., 97:2149-2156, 2016

PubMed Abstract: Orthomyxoviruses are a family of ssRNA virus, including influenza virus, infectious salmon anaemia virus and Thogoto virus. The matrix proteins of orthomyxoviruses play crucial roles in some essential processes of the viral life cycle. However, the mechanisms of the matrix proteins involved in these processes remain incompletely understood. Currently, only the structure and function of the matrix protein from influenza virus have been studied. Here, we present the crystal structures of the N-terminal domain of matrix protein from Thogoto virus at pH 7.0 and 4.5. By analysing the structures, we identified the conformational changes of monomers and dimers in different pH conditions, mainly caused by two flexible loops, L3 and L5. These structural deviations would reflect the basis of viral capsid assembly or disassembly.

PubMed: 27411929
DOI: 10.1099/jgv.0.000551

実験手法

X-RAY DIFFRACTION (1.418 Å)