5HZQ
Crystal structure of cellular retinoic acid binding protein 2 (CRABP2)-aryl fluorosulfate covalent conjugate
Summary for 5HZQ
Entry DOI | 10.2210/pdb5hzq/pdb |
Descriptor | Cellular retinoic acid-binding protein 2, 4'-[(3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy][1,1'-biphenyl]-4-yl sulfurofluoridate, GLYCEROL, ... (4 entities in total) |
Functional Keywords | lipid binding protein, aryl fluorosulfate, retinoic acid |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 32873.53 |
Authors | Chen, W.,Mortenson, D.E.,Wilson, I.A.,Kelly, J.W. (deposition date: 2016-02-02, release date: 2016-06-01, Last modification date: 2023-09-27) |
Primary citation | Chen, W.,Dong, J.,Plate, L.,Mortenson, D.E.,Brighty, G.J.,Li, S.,Liu, Y.,Galmozzi, A.,Lee, P.S.,Hulce, J.J.,Cravatt, B.F.,Saez, E.,Powers, E.T.,Wilson, I.A.,Sharpless, K.B.,Kelly, J.W. Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue. J.Am.Chem.Soc., 138:7353-7364, 2016 Cited by PubMed: 27191344DOI: 10.1021/jacs.6b02960 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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