5HZQ

Crystal structure of cellular retinoic acid binding protein 2 (CRABP2)-aryl fluorosulfate covalent conjugate

Summary for 5HZQ

• Entry DOI: 10.2210/pdb5hzq/pdb
• Descriptor: Cellular retinoic acid-binding protein 2, 4'-[(3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy][1,1'-biphenyl]-4-yl sulfurofluoridate, GLYCEROL, ... (4 entities in total)
• Functional Keywords: lipid binding protein, aryl fluorosulfate, retinoic acid
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 32873.53

Authors

Chen, W.,Mortenson, D.E.,Wilson, I.A.,Kelly, J.W. (deposition date: 2016-02-02, release date: 2016-06-01, Last modification date: 2023-09-27)

• Primary citation: Chen, W.,Dong, J.,Plate, L.,Mortenson, D.E.,Brighty, G.J.,Li, S.,Liu, Y.,Galmozzi, A.,Lee, P.S.,Hulce, J.J.,Cravatt, B.F.,Saez, E.,Powers, E.T.,Wilson, I.A.,Sharpless, K.B.,Kelly, J.W.; Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.; J.Am.Chem.Soc., 138:7353-7364, 2016; PubMed: 27191344; DOI: 10.1021/jacs.6b02960

Experimental method

X-RAY DIFFRACTION (1.75 Å)