5HZQ

Crystal structure of cellular retinoic acid binding protein 2 (CRABP2)-aryl fluorosulfate covalent conjugate

5HZQ の概要

• エントリーDOI: 10.2210/pdb5hzq/pdb
• 分子名称: Cellular retinoic acid-binding protein 2, 4'-[(3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy][1,1'-biphenyl]-4-yl sulfurofluoridate, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: lipid binding protein, aryl fluorosulfate, retinoic acid
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32873.53

構造登録者

Chen, W.,Mortenson, D.E.,Wilson, I.A.,Kelly, J.W. (登録日: 2016-02-02, 公開日: 2016-06-01, 最終更新日: 2023-09-27)

• 主引用文献: Chen, W.,Dong, J.,Plate, L.,Mortenson, D.E.,Brighty, G.J.,Li, S.,Liu, Y.,Galmozzi, A.,Lee, P.S.,Hulce, J.J.,Cravatt, B.F.,Saez, E.,Powers, E.T.,Wilson, I.A.,Sharpless, K.B.,Kelly, J.W.; Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.; J.Am.Chem.Soc., 138:7353-7364, 2016; PubMed: 27191344; DOI: 10.1021/jacs.6b02960

実験手法

X-RAY DIFFRACTION (1.75 Å)