5HZ8

FABP4_3 in complex with 6,8-Dichloro-4-phenyl-2-piperidin-1-yl-quinoline-3-carboxylic acid

5HZ8 の概要

• エントリーDOI: 10.2210/pdb5hz8/pdb
• 分子名称: Fatty acid-binding protein, adipocyte, 6,8-dichloro-4-phenyl-2-(piperidin-1-yl)quinoline-3-carboxylic acid, DIMETHYL SULFOXIDE, ... (4 entities in total)
• 機能のキーワード: lipid binding protein, fatty acid binding protein, cytoplasm, lipid-binding, transport protein, protein binding, _refmac
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P15090
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15774.06

構造登録者

Ehler, A.,Rudolph, M.G. (登録日: 2016-02-02, 公開日: 2016-12-14, 最終更新日: 2024-05-08)

• 主引用文献: Kuhne, H.,Obst-Sander, U.,Kuhn, B.,Conte, A.,Ceccarelli, S.M.,Neidhart, W.,Rudolph, M.G.,Ottaviani, G.,Gasser, R.,So, S.S.,Li, S.,Zhang, X.,Gao, L.,Myers, M.; Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors.; Bioorg. Med. Chem. Lett., 26:5092-5097, 2016; PubMed: 27658368; DOI: 10.1016/j.bmcl.2016.08.071

実験手法

X-RAY DIFFRACTION (1.12 Å)