5HV9

Human LTC4S mutant-S36E

Summary for 5HV9

DescriptorLeukotriene C4 synthase, GLUTATHIONE, SULFATE ION (3 entities in total)
Functional Keywordsltc4s, mutant, lyase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus outer membrane; Multi-pass membrane protein Q16873
Total number of polymer chains1
Total molecular weight17856.97
Authors
Thulasingam, M.,Ahmad, H.R.S.,Rinaldo-Matthis, A.,Haeggstrom, J.Z. (deposition date: 2016-01-28, release date: 2016-07-13, Last modification date: 2017-09-13)
Primary citation
Ahmad, S.,Ytterberg, A.J.,Thulasingam, M.,Tholander, F.,Bergman, T.,Zubarev, R.,Wetterholm, A.,Rinaldo-Matthis, A.,Haeggstrom, J.Z.
Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity.
J.Biol.Chem., 291:18410-18418, 2016
PubMed: 27365393 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M116.735647
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.3121203.7%3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report