5HUG

The crystal structure of neuraminidase from A/American green-winged teal/Washington/195750/2014 influenza virus

5HUG の概要

• エントリーDOI: 10.2210/pdb5hug/pdb
• 関連するPDBエントリー: 5HUK 5HUW 5HVB
• 分子名称: neuraminidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: neuraminidase, influenza virus, h5nx, viral protein
• 由来する生物種: Influenza A virus (A/American green-winged teal/Washington/195750/2014(H5N1))
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44440.23

構造登録者

Yang, H.,Carney, P.J.,Guo, Z.,Chang, J.C.,Stevens, J. (登録日: 2016-01-27, 公開日: 2016-04-13, 最終更新日: 2024-11-13)

主引用文献

Yang, H.,Carney, P.J.,Mishin, V.P.,Guo, Z.,Chang, J.C.,Wentworth, D.E.,Gubareva, L.V.,Stevens, J.
Molecular Characterizations of Surface Proteins Hemagglutinin and Neuraminidase from Recent H5Nx Avian Influenza Viruses.
J.Virol., 90:5770-5784, 2016

PubMed Abstract: During 2014, a subclade 2.3.4.4 highly pathogenic avian influenza (HPAI) A(H5N8) virus caused poultry outbreaks around the world. In late 2014/early 2015, the virus was detected in wild birds in Canada and the United States, and these viruses also gave rise to reassortant progeny, composed of viral RNA segments (vRNAs) from both Eurasian and North American lineages. In particular, viruses were found with N1, N2, and N8 neuraminidase vRNAs, and these are collectively referred to as H5Nx viruses. In the United States, more than 48 million domestic birds have been affected. Here we present a detailed structural and biochemical analysis of the surface antigens of H5N1, H5N2, and H5N8 viruses in addition to those of a recent human H5N6 virus. Our results with recombinant hemagglutinin reveal that these viruses have a strict avian receptor binding preference, while recombinantly expressed neuraminidases are sensitive to FDA-approved and investigational antivirals. Although H5Nx viruses currently pose a low risk to humans, it is important to maintain surveillance of these circulating viruses and to continually assess future changes that may increase their pandemic potential.

PubMed: 27053557
DOI: 10.1128/JVI.00180-16

実験手法

X-RAY DIFFRACTION (1.85 Å)