5HT4
6-substituted pyrrolo[2,3-d]pyrimidine 6-thieno-(4-methoxyphenyl)
Summary for 5HT4
Entry DOI | 10.2210/pdb5ht4/pdb |
Related | 5HT2 |
Descriptor | Dihydrofolate reductase, 7-ethyl-6-[(3-methoxyphenyl)sulfanyl]-5-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | dihydrofolate reductase inhibitor complex with nadph, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Mitochondrion : P00374 |
Total number of polymer chains | 1 |
Total formula weight | 22616.49 |
Authors | Cody, V. (deposition date: 2016-01-26, release date: 2017-02-01, Last modification date: 2023-09-27) |
Primary citation | Cody, V.,Gangjee, A. Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-(4'-methoxyphenythio)[2,3-d]pyrrolo-7-ethyl-2,4-diamines To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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