5HLO

Crystal structure of calcium and zinc-bound human S100A8 in space group C2221

5HLO の概要

• エントリーDOI: 10.2210/pdb5hlo/pdb
• 分子名称: Protein S100-A8, CALCIUM ION, ZINC ION, ... (7 entities in total)
• 機能のキーワード: s100 protein, calcium, zinc, oligomer, signaling protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted: P05109
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 45336.10

構造登録者

Lin, H.,Andersen, G.R.,Yatime, L. (登録日: 2016-01-15, 公開日: 2016-06-08, 最終更新日: 2024-01-10)

主引用文献

Lin, H.,Andersen, G.R.,Yatime, L.
Crystal structure of human S100A8 in complex with zinc and calcium.
Bmc Struct.Biol., 16:8-8, 2016

PubMed Abstract: S100 proteins are a large family of calcium binding proteins present only in vertebrates. They function intra- and extracellularly both as regulators of homeostatic processes and as potent effectors during inflammation. Among these, S100A8 and S100A9 are two major constituents of neutrophils that can assemble into homodimers, heterodimers and higher oligomeric species, including fibrillary structures found in the ageing prostate. Each of these forms assumes specific functions and their formation is dependent on divalent cations, notably calcium and zinc. In particular, zinc appears as a major regulator of S100 protein function in a disease context. Despite this central role, no structural information on how zinc bind to S100A8/S100A9 and regulates their quaternary structure is yet available.

PubMed: 27251136
DOI: 10.1186/s12900-016-0058-4

実験手法

X-RAY DIFFRACTION (2.1 Å)