5HL1

Crystal structure of glutaminase C in complex with inhibitor CB-839

Summary for 5HL1

• Entry DOI: 10.2210/pdb5hl1/pdb
• Related: 5FI2
• Descriptor: Glutaminase kidney isoform, mitochondrial, 2-(pyridin-2-yl)-N-(5-{4-[6-({[3-(trifluoromethoxy)phenyl]acetyl}amino)pyridazin-3-yl]butyl}-1,3,4-thiadiazol-2-yl)acetamide (3 entities in total)
• Functional Keywords: glutaminase, cb-839, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 238973.51

Authors

Huang, Q.,Cerione, R.A. (deposition date: 2016-01-14, release date: 2016-08-24, Last modification date: 2023-09-27)

• Primary citation: Huang, Q.,Katt, W.P.,McDermott, L.A.,Cerione, R.A.; Crystal structure of the clinically relevant glutaminase inhibitot CB-839 in complex with glutaminase C; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)