Crystal structure of glutaminase C in complex with inhibitor CB-839

Summary for 5HL1

DescriptorGlutaminase kidney isoform, mitochondrial, 2-(pyridin-2-yl)-N-(5-{4-[6-({[3-(trifluoromethoxy)phenyl]acetyl}amino)pyridazin-3-yl]butyl}-1,3,4-thiadiazol-2-yl)acetamide (3 entities in total)
Functional Keywordsglutaminase, cb-839, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationIsoform 1: Cytoplasm, cytosol. Isoform 3: Mitochondrion O94925
Total number of polymer chains4
Total molecular weight238973.51
Huang, Q.,Cerione, R.A. (deposition date: 2016-01-14, release date: 2016-08-24, Last modification date: 2017-09-20)
Primary citation
Huang, Q.,Katt, W.P.,McDermott, L.A.,Cerione, R.A.
Crystal structure of the clinically relevant glutaminase inhibitot CB-839 in complex with glutaminase C
To Be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26170.8%2.0%10.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5hl1
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Molmil generated image of 5hl1
rotated about x axis by 90°
Molmil generated image of 5hl1
rotated about y axis by 90°