5HIX

Cocrystal structure of an anti-parallel DNA G-quadruplex and a tetra-Quinoline Foldamer

Summary for 5HIX

• Entry DOI: 10.2210/pdb5hix/pdb
• Descriptor: Dimeric G-quadruplex, POTASSIUM ION, 4-(3-aminopropoxy)-8-({[4-(3-aminopropoxy)-8-({[4-(3-aminopropoxy)-8-({[4-(3-aminopropoxy)-8-nitroquinolin-2-yl]carbonyl}amino)quinolin-2-yl]carbonyl}amino)quinolin-2-yl]carbonyl}amino)quinoline-2-carboxylic acid, ... (4 entities in total)
• Functional Keywords: dna g-quadruplex, foldamer, foldamer-quadruplex, g-quadruplex ligands, dna
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 8788.35

Authors

Mandal, P.K.,Baptiste, B.,Langlois d'Estaintot, B.,Kauffmann, B.,Huc, I. (deposition date: 2016-01-12, release date: 2016-11-02, Last modification date: 2024-01-10)

Primary citation

Mandal, P.K.,Baptiste, B.,Langlois d'Estaintot, B.,Kauffmann, B.,Huc, I.
Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State.
Chembiochem, 17:1911-1914, 2016

PubMed Abstract: Quinoline-based oligoamide foldamers have been identified as a potent class of ligands for G-quadruplex DNA. Their helical structure is thought to target G-quadruplex loops or grooves and not G-tetrads. We report a co-crystal structure of the antiparallel hairpin dimeric DNA G-quadruplex (G T G ) with tetramer 1-a helically folded oligo-quinolinecarboxamide bearing cationic side chains-that is consistent with this hypothesis. Multivalent foldamer-DNA interactions that modify the packing of (G T G ) in the solid state are observed.

PubMed: 27472456
DOI: 10.1002/cbic.201600281

Experimental method

X-RAY DIFFRACTION (2.48 Å)