5HIB

EGFR kinase domain mutant "TMLR" with a pyrazolopyrimidine inhibitor

5HIB の概要

• エントリーDOI: 10.2210/pdb5hib/pdb
• 関連するPDBエントリー: 5HIC
• 分子名称: Epidermal growth factor receptor, N-tert-butyl-5-{[(1-methyl-1H-pyrazol-5-yl)sulfonyl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamide (2 entities in total)
• 機能のキーワード: protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37926.82

構造登録者

Eigenbrot, C.,Yu, C. (登録日: 2016-01-11, 公開日: 2016-04-06, 最終更新日: 2024-03-06)

• 主引用文献: Foster, S.A.,Whalen, D.M.,Ozen, A.,Wongchenko, M.J.,Yin, J.,Yen, I.,Schaefer, G.,Mayfield, J.D.,Chmielecki, J.,Stephens, P.J.,Albacker, L.A.,Yan, Y.,Song, K.,Hatzivassiliou, G.,Eigenbrot, C.,Yu, C.,Shaw, A.S.,Manning, G.,Skelton, N.J.,Hymowitz, S.G.,Malek, S.; Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.; Cancer Cell, 29:477-493, 2016; PubMed: 26996308; DOI: 10.1016/j.ccell.2016.02.010

実験手法

X-RAY DIFFRACTION (2.85 Å)