5HI5

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

Summary for 5HI5

• Entry DOI: 10.2210/pdb5hi5/pdb
• Related: 5HHV 5HHX 5HI3 5HI4
• Descriptor: Interleukin-17A, CAT-2000 FAB heavy chain, CAT-2000 light chain, ... (6 entities in total)
• Functional Keywords: il-17a, psoriasis, md simulation, sulfonyl fluoride, inhibitor, macrocycle, immune system-inhibitor complex, immune system/inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: Q16552
• Total number of polymer chains: 7
• Total formula weight: 128874.97

Authors

Liu, S. (deposition date: 2016-01-11, release date: 2016-08-31, Last modification date: 2024-03-06)

• Primary citation: Liu, S.,Dakin, L.A.,Xing, L.,Withka, J.M.,Sahasrabudhe, P.V.,Li, W.,Banker, M.E.,Balbo, P.,Shanker, S.,Chrunyk, B.A.,Guo, Z.,Chen, J.M.,Young, J.A.,Bai, G.,Starr, J.T.,Wright, S.W.,Bussenius, J.,Tan, S.,Gopalsamy, A.,Lefker, B.A.,Vincent, F.,Jones, L.H.,Xu, H.,Hoth, L.R.,Geoghegan, K.F.,Qiu, X.,Bunnage, M.E.,Thorarensen, A.; Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.; Sci Rep, 6:30859-30859, 2016; PubMed: 27527709; DOI: 10.1038/srep30859

Experimental method

X-RAY DIFFRACTION (1.8 Å)